Major
Forensic Science
Anticipated Graduation Year
2024
Access Type
Open Access
Abstract
Phosphatidylethanol (PEth) is a phase II biomarker formed in the walls of red blood cells that shows excellent sensitivity and specificity as a screening biomarker for chronic alcohol use and abuse. The goal was to develop a “point of care” means of detection and quantitation of PEth to identify alcohol misuse by patients in a clinical setting. This new method is effective at measuring the total amount of ethanol incorporated into the blood phospholipids in whole, dried, and potentially decomposed blood (ex. postmortem). This work is based on US patent 11,085,939 B2 titled “Quantifying Phosphatidylethanol from Blood Samples” published in 2021.
Faculty Mentors & Instructors
James V. DeFrancesco PhD
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Quantifying Phosphatidylethanol from Dried Blood Spots by Gas Chromatography-Mass Spectrometry
Phosphatidylethanol (PEth) is a phase II biomarker formed in the walls of red blood cells that shows excellent sensitivity and specificity as a screening biomarker for chronic alcohol use and abuse. The goal was to develop a “point of care” means of detection and quantitation of PEth to identify alcohol misuse by patients in a clinical setting. This new method is effective at measuring the total amount of ethanol incorporated into the blood phospholipids in whole, dried, and potentially decomposed blood (ex. postmortem). This work is based on US patent 11,085,939 B2 titled “Quantifying Phosphatidylethanol from Blood Samples” published in 2021.