Major
Biology
Anticipated Graduation Year
2024
Access Type
Restricted Access
Abstract
The epidemic of obesity is a major growing personal and public health crisis across the globe. It is estimated that nearly 2/5th of the global adult population is obese, which equates to 650 million adults affected in 2016 (WHO, 2021). According to the Centers for Disease Control and Prevention (CDC), obesity increases the risk of multiple life-threatening diseases and health concerns such as stroke, high blood pressure, coronary artery disease, certain cancers, etc. Overall, the standard of living is dramatically reduced, and can even lead to death.
In this study, we manipulate animals’ diets with isocaloric high- (42% of kcals from fat) and low-fat (15% kcals from fat) diets. Here we report on the genetic basis for variation in fat depots, in levels of sexual dimorphism, and in dietary response, as well as finding the genomic locations associated with the variation of the fat depots.
Faculty Mentors & Instructors
Dr. James Cheverud; Fernando Cipriano Andrade Oliveria
Supported By
National Institute of Diabetes and Digestive and Kidney Diseases grant
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Expression of Genetic Variation in Fat Depot Physiology for Mice
The epidemic of obesity is a major growing personal and public health crisis across the globe. It is estimated that nearly 2/5th of the global adult population is obese, which equates to 650 million adults affected in 2016 (WHO, 2021). According to the Centers for Disease Control and Prevention (CDC), obesity increases the risk of multiple life-threatening diseases and health concerns such as stroke, high blood pressure, coronary artery disease, certain cancers, etc. Overall, the standard of living is dramatically reduced, and can even lead to death.
In this study, we manipulate animals’ diets with isocaloric high- (42% of kcals from fat) and low-fat (15% kcals from fat) diets. Here we report on the genetic basis for variation in fat depots, in levels of sexual dimorphism, and in dietary response, as well as finding the genomic locations associated with the variation of the fat depots.