Major
Neuroscience
Anticipated Graduation Year
2025
Access Type
Open Access
Abstract
Ephs and ephrins are cell surface proteins that act as ligands and receptors for one another and typically mediate contact-dependent axon repulsion. We explored whether there is a role for this signaling system in the rodent tongue. We examined expression patterns of EphAs and ephrinAs in the tongue and geniculate ganglion, in-vitro responses of neurites to ephrinAs, and in-vivo knockouts of ephrinA1, -A3, and -A4. Together, this data supports a role for EphA-ephrinA signaling in axon targeting in the embryonic rodent tongue. Preliminary data shows that EphAs and ephrinAs are expressed in the adult rodent gustatory system as well.
Faculty Mentors & Instructors
Dr. M. William Rochlin, Associate Professor, Biology (Developmental Neurobiology)
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
EPHRINA’S REPEL EMBRYONIC GUSTATORY GENICULATE AXONS IN VITRO AND IN VIVO AND ARE EXPRESSED IN THE ADULT GUSTATORY SYSTEM
Ephs and ephrins are cell surface proteins that act as ligands and receptors for one another and typically mediate contact-dependent axon repulsion. We explored whether there is a role for this signaling system in the rodent tongue. We examined expression patterns of EphAs and ephrinAs in the tongue and geniculate ganglion, in-vitro responses of neurites to ephrinAs, and in-vivo knockouts of ephrinA1, -A3, and -A4. Together, this data supports a role for EphA-ephrinA signaling in axon targeting in the embryonic rodent tongue. Preliminary data shows that EphAs and ephrinAs are expressed in the adult rodent gustatory system as well.