Major
Biology
Anticipated Graduation Year
2025
Access Type
Open Access
Abstract
Cochlea's spiral ganglion neurons (SGNs) transmit sound to the cochlear nucleus, forming a frequency map based on sound responses. Previous studies suggest Ephs and ephrins guide axons in sensory systems, leading us to investigate their role. Ephrin-B2 and EphA7 expression along the cochlear nucleus axis and in developing SGNs respectively implies their involvement in frequency mapping. Ephrin-B2 influences auditory nerve fiber trajectory. Absence of ephrin-B2 and EphA7 in mice reduces frequency band precision. Our findings suggest ephrin-B2 and EphA7 signals regulate frequency mapping in the auditory system.
Faculty Mentors & Instructors
Dr. Wei-Ming Yu, Department of Biology
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Investigate the Role of Ephrin-B2 and EphA7 in Frequency Map Formation in the Cochlear Nucleus
Cochlea's spiral ganglion neurons (SGNs) transmit sound to the cochlear nucleus, forming a frequency map based on sound responses. Previous studies suggest Ephs and ephrins guide axons in sensory systems, leading us to investigate their role. Ephrin-B2 and EphA7 expression along the cochlear nucleus axis and in developing SGNs respectively implies their involvement in frequency mapping. Ephrin-B2 influences auditory nerve fiber trajectory. Absence of ephrin-B2 and EphA7 in mice reduces frequency band precision. Our findings suggest ephrin-B2 and EphA7 signals regulate frequency mapping in the auditory system.