Major
Molecular Biology
Anticipated Graduation Year
2025
Access Type
Open Access
Abstract
The protozoan malaria parasite Plasmodium maintains its cellular shape with a network of cytoskeletal structures under its plasma membrane known as the subpellicular complex. Microtubules play a key part in this stabilizing complex. The novel microtubule inner proteins SPM-1and TrxL-1 are hypothesized to form stabilization complexes inside the microtubules for regulation and structural reinforcement. My project investigates the role of SPM-1 in microtubule stabilization by utilizing a human cell line as a model system. The results of my research will give us new insights into the adaptive mechanisms of the malaria parasite.
Faculty Mentors & Instructors
Dr.Stefan Kanzok, Bansari Joshi
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Investigating the Stabilization Degree in Cold Temperatures of the Microtubule Associated Protein SPM-1 of the Malaria Parasite Plasmodium.
The protozoan malaria parasite Plasmodium maintains its cellular shape with a network of cytoskeletal structures under its plasma membrane known as the subpellicular complex. Microtubules play a key part in this stabilizing complex. The novel microtubule inner proteins SPM-1and TrxL-1 are hypothesized to form stabilization complexes inside the microtubules for regulation and structural reinforcement. My project investigates the role of SPM-1 in microtubule stabilization by utilizing a human cell line as a model system. The results of my research will give us new insights into the adaptive mechanisms of the malaria parasite.