Major
Neuroscience
Anticipated Graduation Year
2029
Access Type
Open Access
Abstract
This project explores how proteins interact with lipid membranes using both simplified model vesicles and more complex native membranes. Small unilamellar vesicles (SUVs) were synthesized and characterized to study lipid binding with bovine serum albumin using fluorescence techniques. While model membranes provide control, they lack the complexity of real cellular environments, so native membranes were also investigated to better capture protein–lipid interactions. By comparing these systems, this work aims to better understand how lipids are transported and delivered within cells, and how these processes influence signaling and membrane protein function.
Faculty Mentors & Instructors
Dr. Manisha Ray, Assistant professor, Chemistry/Biochemistry : Aryana Sayeed, Graduate Researcher, Chemistry/Biochemistry
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Protein-Lipid Interactions Using Model Membrane and Native Membrane Vesicles
This project explores how proteins interact with lipid membranes using both simplified model vesicles and more complex native membranes. Small unilamellar vesicles (SUVs) were synthesized and characterized to study lipid binding with bovine serum albumin using fluorescence techniques. While model membranes provide control, they lack the complexity of real cellular environments, so native membranes were also investigated to better capture protein–lipid interactions. By comparing these systems, this work aims to better understand how lipids are transported and delivered within cells, and how these processes influence signaling and membrane protein function.