Major
Biology
Anticipated Graduation Year
2020
Access Type
Open Access
Abstract
The operations of the proteins encoded by the HIV-1 virus are highly coordinated within the human host. The coordination derives from mutual information expressed in the primary structures. These are the amino acid sequences encoded by the viral genome that carry the requisite information about folding pathways and chemical functions. This project examines the information-convergent properties of HIV-1 proteins that underpin the overlap and reinforcement of functions. The goal is to identify proteins of the virus that express the highest degree of information coordination. These proteins pose compelling targets for small-molecule drug and cocktail therapy and vaccine engineering.
Faculty Mentors & Instructors
Dr. Daniel J. Graham, Professor, Department of Chemistry and Biochemistry
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Information Convergence and Divergence of Protein Primary Structures Encoded by HIV-1
The operations of the proteins encoded by the HIV-1 virus are highly coordinated within the human host. The coordination derives from mutual information expressed in the primary structures. These are the amino acid sequences encoded by the viral genome that carry the requisite information about folding pathways and chemical functions. This project examines the information-convergent properties of HIV-1 proteins that underpin the overlap and reinforcement of functions. The goal is to identify proteins of the virus that express the highest degree of information coordination. These proteins pose compelling targets for small-molecule drug and cocktail therapy and vaccine engineering.