Major
Molecular Biology
Anticipated Graduation Year
2020
Access Type
Open Access
Abstract
Prostate cancer is the most commonly occurring cancer in African American men. The genetic risk for the cancer has been governed by a few rare variants with high penetrance and many commonly occurring variants with lower impact on risk. To better understand the genetic risk for prostate cancer in African Americans, we performed PrediXcan, a transcriptome-wide imputation method that uses reference transcriptome data, in a cohort of nearly 10,000 self-identified African, Latin, and Japanese individuals. We identified 10 genes in African Americans and 4 genes in Japanese Americans to be significantly associated with Prostate Cancer in these populations.
Faculty Mentors & Instructors
Heather E. Wheeler; Associate Professor of Biology, Computer Science, & Public Health; Gregory Matthews; Assistant Professor of Mathematics and Statistics
Supported By
National Institute of Health-1R15HG009569-01
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Transcriptome-Wide Association Study of Prostate Cancer in Diverse Populations
Prostate cancer is the most commonly occurring cancer in African American men. The genetic risk for the cancer has been governed by a few rare variants with high penetrance and many commonly occurring variants with lower impact on risk. To better understand the genetic risk for prostate cancer in African Americans, we performed PrediXcan, a transcriptome-wide imputation method that uses reference transcriptome data, in a cohort of nearly 10,000 self-identified African, Latin, and Japanese individuals. We identified 10 genes in African Americans and 4 genes in Japanese Americans to be significantly associated with Prostate Cancer in these populations.