Major

Biology

Anticipated Graduation Year

Fourth Year

Access Type

Restricted Access

Abstract

The vertebrate Type II Collagen alpha-1 gene (Col2α1) gene has an important role in the regulation of craniofacial development. The project focuses on the gene regulation and expression of the zebrafish gene Col2α1a – an ortholog of the human COL2α1 gene that has a major role in cartilage development and bone growth. The goal is to observe the early development of zebrafish during the overexpression and knockdown of co12α1a in their genome. Observing the effects of Col2α1a overexpression and knockdown on VWF-C and BMP will help our lab understand the expression and regulation of Col2α1 in vertebrate development.

Community Partners

N/A

Faculty Mentors & Instructors

Dr. Rodney M. Dale, PhD, Biology Department

Supported By

N/A

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.

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Elucidating the Function of an Evolutionarily Conserved Embryonic Splice Variant of Type II Collagen During Vertebrate Development

The vertebrate Type II Collagen alpha-1 gene (Col2α1) gene has an important role in the regulation of craniofacial development. The project focuses on the gene regulation and expression of the zebrafish gene Col2α1a – an ortholog of the human COL2α1 gene that has a major role in cartilage development and bone growth. The goal is to observe the early development of zebrafish during the overexpression and knockdown of co12α1a in their genome. Observing the effects of Col2α1a overexpression and knockdown on VWF-C and BMP will help our lab understand the expression and regulation of Col2α1 in vertebrate development.