Major
Biology
Anticipated Graduation Year
Fourth Year
Access Type
Restricted Access
Abstract
The vertebrate Type II Collagen alpha-1 gene (Col2α1) gene has an important role in the regulation of craniofacial development. The project focuses on the gene regulation and expression of the zebrafish gene Col2α1a – an ortholog of the human COL2α1 gene that has a major role in cartilage development and bone growth. The goal is to observe the early development of zebrafish during the overexpression and knockdown of co12α1a in their genome. Observing the effects of Col2α1a overexpression and knockdown on VWF-C and BMP will help our lab understand the expression and regulation of Col2α1 in vertebrate development.
Community Partners
N/A
Faculty Mentors & Instructors
Dr. Rodney M. Dale, PhD, Biology Department
Supported By
N/A
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Elucidating the Function of an Evolutionarily Conserved Embryonic Splice Variant of Type II Collagen During Vertebrate Development
The vertebrate Type II Collagen alpha-1 gene (Col2α1) gene has an important role in the regulation of craniofacial development. The project focuses on the gene regulation and expression of the zebrafish gene Col2α1a – an ortholog of the human COL2α1 gene that has a major role in cartilage development and bone growth. The goal is to observe the early development of zebrafish during the overexpression and knockdown of co12α1a in their genome. Observing the effects of Col2α1a overexpression and knockdown on VWF-C and BMP will help our lab understand the expression and regulation of Col2α1 in vertebrate development.