Presenter Information

Omar ZahraFollow

Major

Chemistry

Anticipated Graduation Year

2020

Access Type

Open Access

Abstract

Hydroxypropyl methylcellulose (HPMC) is a target polymer that has been found to be an efficient way to manipulate the release rate of the active pharmaceutical ingredient in a drug. Our goal is to use Molecular Dynamics (MD) to determine the interaction of HPMC with SDS over four locations GP2, GP6, GM2, and GM6. The surfactant is placed in an environment with HPMC where a water box is created. The overall goal is to generate results that will allow pharmaceutical companies to better select inactive ingredients in drugs reducing the side effects and essentially improving patient’s quality of life.

Faculty Mentors & Instructors

Dr. Ken Olsen, Professor, Department of Chemistry and Biochemistry

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.

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Molecular Dynamics of HPMC/SDS Interactions

Hydroxypropyl methylcellulose (HPMC) is a target polymer that has been found to be an efficient way to manipulate the release rate of the active pharmaceutical ingredient in a drug. Our goal is to use Molecular Dynamics (MD) to determine the interaction of HPMC with SDS over four locations GP2, GP6, GM2, and GM6. The surfactant is placed in an environment with HPMC where a water box is created. The overall goal is to generate results that will allow pharmaceutical companies to better select inactive ingredients in drugs reducing the side effects and essentially improving patient’s quality of life.