Major

Forensic Studies

Anticipated Graduation Year

Senior

Access Type

Open Access

Abstract

The subject compound, 1,3-dimethylamylamine (DMAA), is a “natural” stimulant found in nutritional supplements, weight loss, and athletic performance-enhancing products. This amphetamine-like compound is linked to cardiovascular problems such as shortness of breath, arrhythmias, chest tightness, heart attacks, and multiple deaths [ref 1]. DMAA was banned in 2010 by the International Association of Athletics and the International Olympic Committee which both abide by the policies set forth by the World Anti-Doping Agency [ref 2]. Our laboratory recently developed a quantitative method to determine the presence and amount of DMAA in commercial products by GC-FID and GC-MS. The purpose of this project was to optimize the sensitivity of the existing analytical method to quantitate DMAA via derivatization using alkanoic anhydrides of varying molecular weight.

Faculty Mentors & Instructors

Dr. James V. DeFrancesco, Senior Lecturer, Forensic Science/Chemistry and Biochemistry

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.

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Optimization of GC Assay for 1,3-dimethylamylamine

The subject compound, 1,3-dimethylamylamine (DMAA), is a “natural” stimulant found in nutritional supplements, weight loss, and athletic performance-enhancing products. This amphetamine-like compound is linked to cardiovascular problems such as shortness of breath, arrhythmias, chest tightness, heart attacks, and multiple deaths [ref 1]. DMAA was banned in 2010 by the International Association of Athletics and the International Olympic Committee which both abide by the policies set forth by the World Anti-Doping Agency [ref 2]. Our laboratory recently developed a quantitative method to determine the presence and amount of DMAA in commercial products by GC-FID and GC-MS. The purpose of this project was to optimize the sensitivity of the existing analytical method to quantitate DMAA via derivatization using alkanoic anhydrides of varying molecular weight.