Major
Biology
Anticipated Graduation Year
2021
Access Type
Open Access
Abstract
The development of new classifications of inhibitors is essential in order to control infectious diseases. Currently the only antibiotics available follow two approaches: inhibition of cell wall remodeling and protein synthesis. DapE is part of the succinylase biosynthetic pathway and is important to the production of lysine and mDap both of which synthesize protein and bacterial peptidoglycan cell wall remodeling. There is no evidence of DapE in mammals, therefore, inhibition should be essential in antibiotic development.
Faculty Mentors & Instructors
Kenneth Olsen, Biochemistry Department; Daniel Becker, Chemistry Department; Matt Kochert, Graduate Student
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Synthesizing DapE Inhibitors through Molecular Dynamic Simulations
The development of new classifications of inhibitors is essential in order to control infectious diseases. Currently the only antibiotics available follow two approaches: inhibition of cell wall remodeling and protein synthesis. DapE is part of the succinylase biosynthetic pathway and is important to the production of lysine and mDap both of which synthesize protein and bacterial peptidoglycan cell wall remodeling. There is no evidence of DapE in mammals, therefore, inhibition should be essential in antibiotic development.