Presenter Information

Kristeen BeblaFollow

Major

Biology

Anticipated Graduation Year

2021

Access Type

Open Access

Abstract

The development of new classifications of inhibitors is essential in order to control infectious diseases. Currently the only antibiotics available follow two approaches: inhibition of cell wall remodeling and protein synthesis. DapE is part of the succinylase biosynthetic pathway and is important to the production of lysine and mDap both of which synthesize protein and bacterial peptidoglycan cell wall remodeling. There is no evidence of DapE in mammals, therefore, inhibition should be essential in antibiotic development.

Faculty Mentors & Instructors

Kenneth Olsen, Biochemistry Department; Daniel Becker, Chemistry Department; Matt Kochert, Graduate Student

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.

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Synthesizing DapE Inhibitors through Molecular Dynamic Simulations

The development of new classifications of inhibitors is essential in order to control infectious diseases. Currently the only antibiotics available follow two approaches: inhibition of cell wall remodeling and protein synthesis. DapE is part of the succinylase biosynthetic pathway and is important to the production of lysine and mDap both of which synthesize protein and bacterial peptidoglycan cell wall remodeling. There is no evidence of DapE in mammals, therefore, inhibition should be essential in antibiotic development.