Major
Neuroscience
Anticipated Graduation Year
2020
Access Type
Open Access
Abstract
Our preliminary results also demonstrated that ephrin-A3 molecules are expressed along the tonotopic axis of the cochlear nucleus during development, suggesting they could have a role in tonotopic map formation. To investigate a role of ephrin-A3 molecules in auditory circuit formation, I will examine hearing functions of ephrin-A3 mutant mice by recording auditory brainstem responses and assessing frequency discrimination in mutant mice using an acoustic startle-based approach. These assays will allow me to evaluate whether ephrin-A3 mutant mice have any hearing deficits and whether ephrin-A3 molecules play an essential role in auditory circuit formation
Faculty Mentors & Instructors
Dr. Wei-Ming Yu
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Investigate the role of ephrin-A3 in Tonotopic Map Formation of the Mouse Cochlear Nucleus
Our preliminary results also demonstrated that ephrin-A3 molecules are expressed along the tonotopic axis of the cochlear nucleus during development, suggesting they could have a role in tonotopic map formation. To investigate a role of ephrin-A3 molecules in auditory circuit formation, I will examine hearing functions of ephrin-A3 mutant mice by recording auditory brainstem responses and assessing frequency discrimination in mutant mice using an acoustic startle-based approach. These assays will allow me to evaluate whether ephrin-A3 mutant mice have any hearing deficits and whether ephrin-A3 molecules play an essential role in auditory circuit formation