Presenter Information

Masha BandouilFollow

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Major

Biology

Anticipated Graduation Year

2021

Access Type

Open Access

Abstract

As part of the Genomics Education Partnership, The Pathways Project aims to annotate genes involved in the Insulin signaling pathway in all of the Drosophila species in order to better understand how well the Insulin pathway has been conserved throughout evolution. For my contribution to this project, I annotated the widerborst gene (wdb) which is part of the Insulin signaling pathway as it encodes the B’ regulatory subunit of PP2A. Gene annotation is the process of developing a gene model which details the exact positions of coding exons in a gene. Through using tools like BLAST, the UCSC Genome Browser, and Flybase, the gene annotation process is done using synteny with a well characterized species which, in this case, was D. Melanogaster. Through my work, I evaluated the degree of conservation of the wdb gene in two Drosophila species: D. Elegans and D. Virilis.

Community Partners

Genomics Education Partnership

Faculty Mentors & Instructors

Dr. Jennifer Mierisch, Assistant Professor, Department of Biology

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.

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Gene Annotation of wdb Across Drosophila Species

As part of the Genomics Education Partnership, The Pathways Project aims to annotate genes involved in the Insulin signaling pathway in all of the Drosophila species in order to better understand how well the Insulin pathway has been conserved throughout evolution. For my contribution to this project, I annotated the widerborst gene (wdb) which is part of the Insulin signaling pathway as it encodes the B’ regulatory subunit of PP2A. Gene annotation is the process of developing a gene model which details the exact positions of coding exons in a gene. Through using tools like BLAST, the UCSC Genome Browser, and Flybase, the gene annotation process is done using synteny with a well characterized species which, in this case, was D. Melanogaster. Through my work, I evaluated the degree of conservation of the wdb gene in two Drosophila species: D. Elegans and D. Virilis.