Presenter Information

Elizabeth KojakFollow

Major

Chemistry

Anticipated Graduation Year

2022

Access Type

Restricted Access

Abstract

Determining the three-dimensional structure of a protein is essential for identifying its function, localization, and how it interacts with other structures in the cell. Phosducin- like proteins (PhLP) are highly-conserved cytosolic proteins in eukaryotes which are hypothesized to function as co-chaperones in the folding of cytoskeletal proteins actin and tubulin. Although this family of proteins is highly-conserved among eukaryotes of ranging complexity, very few representative species have been characterized. As part of Dr. Kanzok’s team, our objective is to determine the three-dimensional structure of PhLP-3 from Plasmodium, Drosophila, and humans in order to better understand both its function and mechanism.

Faculty Mentors & Instructors

Dr. Stefan Kanzok, Biology Department

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.

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Structure and function of phosducin-like protein 3 from three model organisms

Determining the three-dimensional structure of a protein is essential for identifying its function, localization, and how it interacts with other structures in the cell. Phosducin- like proteins (PhLP) are highly-conserved cytosolic proteins in eukaryotes which are hypothesized to function as co-chaperones in the folding of cytoskeletal proteins actin and tubulin. Although this family of proteins is highly-conserved among eukaryotes of ranging complexity, very few representative species have been characterized. As part of Dr. Kanzok’s team, our objective is to determine the three-dimensional structure of PhLP-3 from Plasmodium, Drosophila, and humans in order to better understand both its function and mechanism.