Major
Biology
Anticipated Graduation Year
2023
Access Type
Open Access
Abstract
Spermatogenesis is essential for the production of sperm for sexual reproduction. Defects in this process can lead to infertility. In order to understand the basis of infertility it is necessary to identify and characterize the genetic mechanisms that promote sperm development. My research has been focused on discovering the relationship between the gene Notch, and the transcription factors ribbon and hindsight. Our experiments suggest that Notch regulates hindsight and may have an antagonistic relationship with ribbon. We plan to further explore the relationship between Notch, ribbon and Hnt to better understand how these genes and their mammalian homologs promote spermatogenesis.
Faculty Mentors & Instructors
Jennifer Mierisch, Associate Professor, Biology Department
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Regulation of Spermatogenesis by Notch Signaling
Spermatogenesis is essential for the production of sperm for sexual reproduction. Defects in this process can lead to infertility. In order to understand the basis of infertility it is necessary to identify and characterize the genetic mechanisms that promote sperm development. My research has been focused on discovering the relationship between the gene Notch, and the transcription factors ribbon and hindsight. Our experiments suggest that Notch regulates hindsight and may have an antagonistic relationship with ribbon. We plan to further explore the relationship between Notch, ribbon and Hnt to better understand how these genes and their mammalian homologs promote spermatogenesis.