Presenter Information

Ahmad AlzeinFollow

Major

Neuroscience

Anticipated Graduation Year

2020

Access Type

Open Access

Abstract

Sound information is transmitted to the central nervous system via spiral ganglion neurons (SGNs) in the cochlea. SGNs innervate the cochlear nucleus in the brainstem in a tonotopic fashion, meaning the neurons are organized by their responses to different sound frequencies. Ephs and ephrins signaling molecules are known to be involved in axon guidance and have been shown to play a role in development of topographic gradients in other sensory systems. In this study we are investigating the role of ephrin-A3 in the tonotopic map formation in the mouse cochlear nucleus by using ephrin stripe assays and ABR analysis.

Faculty Mentors & Instructors

Dr. Wei-Ming Yu and Dr. Natalia Hoshino

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.

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Investigating the role of ephrin-A3 in Tonotopic Map Formation of the Mouse Cochlear Nucleus

Sound information is transmitted to the central nervous system via spiral ganglion neurons (SGNs) in the cochlea. SGNs innervate the cochlear nucleus in the brainstem in a tonotopic fashion, meaning the neurons are organized by their responses to different sound frequencies. Ephs and ephrins signaling molecules are known to be involved in axon guidance and have been shown to play a role in development of topographic gradients in other sensory systems. In this study we are investigating the role of ephrin-A3 in the tonotopic map formation in the mouse cochlear nucleus by using ephrin stripe assays and ABR analysis.