Major
Bioinformatics
Anticipated Graduation Year
2020
Access Type
Open Access
Abstract
The development of effective treatments is vital in the fight against cancer, the second leading cause of death globally. Cancer is a personalized disease without an overarching cure, thus it is important to consider how genetic variation affects the drug response of individuals. After performing both GWAS and TWAS, we discovered several novel SNPs as well as two genes to be significantly associated with chemotherapy cytotoxicity within and across different ethnic cohorts. By identifying variants associated with toxicity, we strive to understand how genetic factors impact the effectiveness of existing chemotherapy drugs and enable future developments in precision medicine.
Community Partners
University of Chicago
Faculty Mentors & Instructors
Heather E. Wheeler, Associate Professor, Biology and Computer Science Departments
Supported By
Claudia Wing, Senior Research Scientist, University of Chicago; M. Eileen Dolan, Professor, University of Chicago
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Genetics of Chemotherapy Toxicity in Human Lymphoblastoid Cell Lines from Diverse Populations
The development of effective treatments is vital in the fight against cancer, the second leading cause of death globally. Cancer is a personalized disease without an overarching cure, thus it is important to consider how genetic variation affects the drug response of individuals. After performing both GWAS and TWAS, we discovered several novel SNPs as well as two genes to be significantly associated with chemotherapy cytotoxicity within and across different ethnic cohorts. By identifying variants associated with toxicity, we strive to understand how genetic factors impact the effectiveness of existing chemotherapy drugs and enable future developments in precision medicine.