Major

Neuroscience

Anticipated Graduation Year

2020

Access Type

Open Access

Abstract

Our preliminary results also demonstrated that ephrin-A3 molecules are expressed along the tonotopic axis of the cochlear nucleus during development, suggesting they could have a role in tonotopic map formation. To investigate a role of ephrin-A3 molecules in auditory circuit formation, I will examine hearing functions of ephrin-A3 mutant mice by recording auditory brainstem responses and assessing frequency discrimination in mutant mice using an acoustic startle-based approach. These assays will allow me to evaluate whether ephrin-A3 mutant mice have any hearing deficits and whether ephrin-A3 molecules play an essential role in auditory circuit formation

Faculty Mentors & Instructors

Dr. Wei-Ming Yu

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.

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Investigate the role of ephrin-A3 in Tonotopic Map Formation of the Mouse Cochlear Nucleus

Our preliminary results also demonstrated that ephrin-A3 molecules are expressed along the tonotopic axis of the cochlear nucleus during development, suggesting they could have a role in tonotopic map formation. To investigate a role of ephrin-A3 molecules in auditory circuit formation, I will examine hearing functions of ephrin-A3 mutant mice by recording auditory brainstem responses and assessing frequency discrimination in mutant mice using an acoustic startle-based approach. These assays will allow me to evaluate whether ephrin-A3 mutant mice have any hearing deficits and whether ephrin-A3 molecules play an essential role in auditory circuit formation